PERFECT WHITE EMULSION 正在使用的成分被官方证实有效地消除皮肤黑斑, 并且对人体无害
此全天然特效祛斑面霜,专门研制以阻止黑色素形成,不漂白,不剥落,以医学美容技术彻底克服黑斑并恢复和提高肌肤的透明感与光泽,其独特的配方巧妙地运用苯间苯二酚和环己二醇二乙基己酸,前者为酪氨酸酶黑色素抑制剂,后者为抑制B16色素信号细胞 的活跃。
于此双管齐下的调理方法,肯定达到一个白皙而完美无瑕的,透明感的,如丝般平滑的外观。
不只如此,此配方结合天然乳酸可润泽表皮并促进角质层剥落,激励新细胞的生长。并且融合独特的混合三胜肽,即刻渗入皮肤增进胶原蛋白合成,抚平皱纹和细纹。
Cyclohexanediol bis-ethylhexanoate inhibits melanogenesis of
murine B16 melanoma and UV-induced pigmentation in human skin.
The role of cyclohexane diester analogues in the formation
of melanin has been recently reported. In the present study, we investigated
the inhibitory effect of cyclohexanediol bis-ethylhexanoate (CHEH) on
melanogenesis in B16 melanoma cells and on UV-B-induced pigmentation in human
skin. CHEH significantly reduced the melanin content in a dose-dependent
manner, without cytotoxic effects at the effective concentrations. Moreover,
CHEH dose-dependently inhibited tyrosinase activity in B16 melanoma cells, as
confirmed by Western blot analysis of the tyrosinase protein levels. However,
tyrosinase transcript levels remained unchanged under the same experimental
conditions. These results indicate that CHEH inhibited melanogenesis in B16
melanoma cells by regulating tyrosinase activity at the post-transcriptional
level. On the other hand, in a cell-free system, CHEH did not inhibit
tyrosinase activity. This indicated that CHEH suppressed the pigmentation of
melanocytes by indirectly regulating tyrosinase activity. Finally, in a
clinical trial, a cream containing 1.0% CHEH showed good whitening effect on
UV-induced pigmented human skin without adverse effects. In conclusion, we
suggest that CHEH may be an effective inhibitor of melanogenesis and useful
effects in the treatment of hyperpigmented disorders.
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